68 Clinical Trials jobs in South Africa

Minimum Requirements

• Master's degree in science, immunology, medicine, microbiology, public health or associated allied health professions.
• Previous clinical trial conduct experience.
• Previous demonstrable project management experience.
• ICH (R3) and SA GCP certification.
• Computer literate and advanced skills with MS Office and MS Project.
• Previous eTMF or eISF software experience would be advantageous.

Personal Qualities and Competencies

• Strong attention to detail with a commitment to accuracy and data integrity.
• Excellent organizational and time management skills with the ability to manage multiple priorities under tight timelines.
• Effective communication and interpersonal skills to foster collaborative relationships across multidisciplinary teams.
• Ability to work proactively and independently, while also being a strong team player.
• Analytical and problem-solving skills with a practical, solutions-oriented approach.
• High level of integrity, discretion, and professionalism in handling confidential information.
• Adaptability and resilience in a fast-paced, dynamic early-phase research environment.

Key Responsibilities

• Co-ordinate the activities of the VM-CTU in accordance with the unit milestones and timelines.
• Convene routine meetings on behalf of the VM-CTU PI with funders, collaborators, sponsors (where applicable), site clinical trial teams and trial monitors. Including compiling and distribution of meeting summaries and tracking of action items.
• Provide JSC, PSRT, DSMB secretariat support (advance meeting scheduling and meeting summary coordination and distribution).
• Coordinate with the mucosal immunology laboratory, head of laboratory trial statisticians and data management to ensure the secure storage and curation of laboratory and basic science data that are batch processed from local and international laboratories.
• Report writing in accordance with funder requirements.
• Science presentation and medical writing support to the Principal Investigator.

Job Types: Full-time, Permanent

Work Location: In person

Seeking clinical trial investigator to provide comprehensive medical care/clinical support to participants enrolled into clinical trials at TREAD Research.

Start date : 1 November 2025

1-2 years clinical trial experience is a requirement

Open to work half-day = 7am - 1pm

Key Performance areas:

• Provision of clinical care to patients and participants
• Accurate and comprehensive medical record keeping
• Clinical trial oversight or management as designated by the principal investigator
• Participation in all phases/components of the research process
• Facilitation and resolution of queries from Data Management and Internal/ External Monitors within required timeframe
• Quality Check of Source Documents during participant visit ensuring any outstanding components are proactively addressed

Required minimum education and training:

• Medical Degree (MBCHB)Qualified as Medical Doctor
• Professional body registration: Registered with the Health Professions Council of South Africa
• Excellent clinical skills and attention to detail
• Ability to work under pressure and work well across multiple different projects and teams
• Empathy and sensitivity toward people from key populations

Job Types: Full-time, Part-time

Expected hours: 42.5 per week

Work Location: In person

Expected Start Date: 2025/11/01

CAPRISA is an award-winning global research organisation located on the campus of the Nelson R Mandela School of Medicine in Durban, South Africa and undertakes research in HIV, TB and Covid at four clinical research sites in KwaZulu-Natal. CAPRISA's goal is to undertake globally relevant and locally responsive research that contributes to understanding HIV Vaccines and Pathogenesis, Prevention and Epidemiology, the links between Tuberculosis and AIDS treatment and Covid-19. CAPRISA is a UNAIDS Collaborating Centre for HIV Research and Policy and is recognised as a DSI-NRF Centre of Excellence in HIV Prevention and hosts the SAMRC HIV-TB Pathogenesis and Treatment Research Unit.

The successful incumbent will join the CAPRISA Gates Foundation Vaginal Microbiome Clinical Trials Unit (VM-CTU) and will be based at the CAPRISA Headquarters in Durban.

• A bachelor's degree in a health-related or life sciences discipline (e.g., Pharmacy, Nursing, Medical Sciences, Clinical Research, or equivalent).
• At least 2–3 years of experience monitoring clinical trials with knowledge of clinical trials operations, preferably early-phase (Phase I/II) studies.
• Solid knowledge of SA GCP guidelines, ICH-GCP guidelines, South African Ethics in Health Research Guidelines, SAHPRA and international regulatory requirements.
• Prior experience in monitoring and/or trial coordination, within an academic or as a CRA in industry-sponsored trial setting.
• Strong understanding of investigational product accountability, safety reporting, and protocol compliance.
• Proficiency in MS Office (Word, Excel, PowerPoint, Outlook) and familiarity with electronic data capture (EDC) systems.
• Experience working within a multidisciplinary research environment is an advantage.

• Assume the role of regional monitor for all trials conducted in the VM-CTU for an estimated 5 trials per annum.
• Develop and maintain Standard Operating Procedures relevant to the portfolio.
• Create trial monitoring plans in conjunction with the trial sponsor representatives.
• Conduct study initiation visits for each new trial protocol to assess site readiness for study activation.
• Conduct trial monitoring (clinic, laboratory and pharmacy) to ensure compliance with study protocols, SOPs, ICH-GCP, and local regulatory requirements.
• Review case report forms (CRFs), source documents, and data entry to verify accuracy, completeness, and timeliness.
• Monitor and track protocol deviations, adverse events (AEs/SAEs), and data queries.
• Review essential study documentation, including trial master file (eTMF) and investigator site file (eISF).
• Prepare monitoring reports, progress updates, and assist with audits and inspection preparation.
• Contribute to quality assurance initiatives and continuous improvement of trial conduct at the unit.
• Support close-out activities, ensuring data integrity and regulatory compliance are maintained throughout the trial lifecycle.

Role Description

This is a full-time, on-site role for a Clinical Research Associate based in Durban. The Clinical Research Associate will oversee the daily operations of clinical trials, ensure compliance with protocols, and manage research activities. Responsibilities include coordinating with clinical trial sites, monitoring the progress of studies, and maintaining accurate documentation. The role involves close collaboration with other clinical research professionals to ensure the integrity and quality of the research data.

Responsibilities:

• Assume the role of regional monitor for all trials conducted in the VM-CTU for an estimated 5 trials per annum.
• Develop and maintain Standard Operating Procedures relevant to the portfolio.
• Create trial monitoring plans in conjunction with the trial sponsor representatives.
• Conduct study initiation visits for each new trial protocol to assess site readiness for study activation.
• Conduct trial monitoring (clinic, laboratory and pharmacy) to ensure compliance with study protocols, SOPs, ICH-GCP, and local regulatory requirements.
• Review case report forms (CRFs), source documents, and data entry to verify accuracy, completeness, and timeliness.

Qualifications

• A bachelor's degree in a health-related or life sciences discipline (e.g., Pharmacy, Nursing, Medical Sciences, Clinical Research, or equivalent).
• At least 2–3 years of experience monitoring clinical trials with knowledge of clinical trials operations, preferably early-phase (Phase I/II) studies.
• Solid knowledge of SA GCP guidelines, ICH-GCP guidelines, South African Ethics in Health Research Guidelines, SAHPRA and international regulatory requirements.
• Prior experience in monitoring and/or trial coordination, within an academic or as a CRA in industry-sponsored trial setting.
• Strong understanding of investigational product accountability, safety reporting, and protocol compliance.
• Proficiency in MS Office (Word, Excel, PowerPoint, Outlook) and familiarity with electronic data capture (EDC) systems.
• Experience working within a multidisciplinary research environment is an advantage.

Position
: Clinical Research Nurse

Location:
Bloemfontein – Office based

Job Type:
Full-time

Division:
Clinic

Closing date:
19 September 2025

About Us:

Are you ready to be part of a pioneering force in clinical research? With a rich history dating back to 1974, FARMOVS has been at the forefront of accelerating product development through innovative ICH GCP compliant phase 1-2a clinical trials. Having conducted over 3000 trials at our esteemed facility, we offer unmatched expertise and experience in the field.

At FARMOVS, we pride ourselves on our extensive capabilities, including a GLP certified bioanalytical laboratory, registered pharmacy, and a cutting-edge 98-bed clinic equipped with an ISO 15189 accredited clinical laboratory.

Together, we are pushing the boundaries of medical science and improving lives through groundbreaking clinical research. We collaborate with top-tier institutions and sponsors to conduct clinical trials that pave the way for new treatments and therapies.

Located on the vibrant campus of the University of the Free State in Bloemfontein, central South Africa, FARMOVS offers a dynamic and stimulating work environment.

Position overview:

Are you a compassionate, detail-oriented nursing professional with a passion for advancing healthcare? Then this is the job for you We are seeking a skilled Clinical Research Nurse to join our dynamic team at FARMOVS. A Clinical Research Nurse plays a pivotal role in the healthcare and research sector by coordinating and managing clinical trials according to clinical study protocols, South African and ICH GCP Guidelines and SOPs and ensuring the integrity of the research process while prioritizing patient care.

What we are looking for:

Key Accountabilities:

• Review protocol, Clinical Report Form (CRF) and other related functions (e.g. data transcribing).
• Assist in the recruitment of Trial participants,
• Preparation for execution of studies (e.g. prepare source data), screening and execution of studies.
• Ensure accurate collection, recording, and reporting of trial data in compliance with ethical and regulatory standards.
• Support and educate participants about clinical trials while safeguarding their rights and wellbeing.
• Perform verification and operational QC procedures.
• Working on nominated projects / ad hoc project work and any other protocol specific procedures applicable for which training is given.
• Willing to work flexible hours in terms of day shift and possible night shift hours.

Skills:

• Thorough knowledge of applicable international and local guidelines and regulations (e.g. South African & ICH GCP), SOP's and Basic Life Support;
• Excellent interpersonal, verbal and written communication skills;
• Ability to manage multiple and varied tasks with enthusiasm and prioritize workload with attention to detail;
• Ability to motivate volunteers to be reliable and responsible whilst participating in trials;
• Self-motivated with a willingness to accept responsibility and challenges;
• Ability to work in a team and have a flexible attitude;
• Computer skills; ability to use MS Word, Excel, Outlook;
• Accurate execution of protocol related procedures;
• Able to work independently and with initiative.

Education and Experience:

• B Degree/Diploma in nursing
• Registration with SANC
• Current BLS or ACLS certification
• 2 years' experience as a registered nurse

Why Join Us?

At FARMOVS, you will be part of a collaborative team working on innovative projects that make a real difference. We value teamwork, quality, and a commitment to excellence. If you are ready to take on new challenges and grow your career in Information Technology in the Clinical research environment, we would love to hear from you

How to Apply:

If you are eager to contribute to groundbreaking clinical research and interested in joining our dynamic team, please send your CV to and we will contact you. Should you not receive a personal response from us within two to three weeks after the closing date of the vacancy, you can consider your application to have been unsuccessful.

FARMOVS is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

Job Title: Clinical Research Site Leader

Department: Research Department

Reports to: Head of Research

Location: Ndevana, Buffalo City Metropolitan Municipality in the Eastern Cape

Annual Salary Range: R737 796 – R1 009 077 (Depending on experience)

Purpose of the Role

Together with our client, we are recruiting for a Clinical Research Site Leader based in Zintenteni, Ndevana in the Eastern Cape. The Site Leader will provide administrative and operational leadership in the implementation of multiple clinical trials at the site. This role is accountable for site management, stakeholder coordination, staff supervision, reporting, SOP compliance, and team development, ensuring the successful delivery of all study outcomes.

Key Responsibilities:

1. Project Management

• Oversee and implement multiple studies according to timelines, ensuring compliance with GCP, study protocols, SOPs and sponsor requirements.
• Standardise processes for planning, activation, recruitment, enrolment, data cleaning and study close-out.
• Monitor study progress and ensure all performance targets are met.
• Prepare progress reports for funders and stakeholders.
• Collaborate with Principal Investigators to resolve internal and external monitoring findings.
• Ensure accurate maintenance of essential documents and Investigator Site Files.
• Attend community and stakeholder meetings to present study updates.
• Contribute to the development and review of SOPs.

1. Site Management

• Ensure daily operational readiness of the site and clinic facility.
• Allocate staff effectively across multiple studies.
• Conduct regular performance and capacity evaluations.
• Initiate recruitment processes when additional staffing resources are required.
• Act as the primary contact for sponsors and stakeholders.
• Support feasibility assessments by providing accurate site data and capabilities.

1. Staff Training & Mentorship

• Supervise and mentor research staff.
• Conduct training and retraining based on quality assessments and audit feedback.
• Guide staff in development of publications, abstracts, and presentations.
• Promote ongoing professional development.

1. Research Outputs

• Lead or contribute to scientific publications and dissemination activities.
• Lead or support the writing of grant proposals.

Qualifications & Registrations:

• Master’s Degree in Biomedical/Health or related field (Essential)
• Management Qualification (Essential)
• HPCSA Registration, if applicable
• PhD in a Biomedical/Health related field (advantageous).
• Project Management Certificate
• GCP Certification (Advantageous)

Experience:

• Minimum 5 years’ clinical trial management (Essential)
• Minimum 3 years’ clinical research site leadership (Essential)
• Strong understanding of South African regulatory requirements (SAHPRA, Ethics submissions, etc.)
• Experience with study documentation (protocols, CRFs, SOPs)
• Proven track record in publications and grant writing

Additional Requirements:

• Proficiency in English (Essential); Xhosa (Advantageous)
• Proficiency in Microsoft Office
• Ability to utilise Artificial Intelligence (AI) to improve operations
• Willingness to work flexible hours, including weekends as required
• Valid Driver’s License (Essential)

Application Process:

Job Title: Clinical Research Site Leader

Department: Research Department

Reports to: Head of Research

Location: Ndevana, Buffalo City Metropolitan Municipality in the Eastern Cape

Annual Salary Range: R737 796 – R1 009 077 (Depending on experience)

Purpose of the Role

Together with our client, we are recruiting for a Clinical Research Site Leader based in Zintenteni, Ndevana in the Eastern Cape. The Site Leader will provide administrative and operational leadership in the implementation of multiple clinical trials at the site. This role is accountable for site management, stakeholder coordination, staff supervision, reporting, SOP compliance, and team development, ensuring the successful delivery of all study outcomes.

Key Responsibilities:

1. Project Management

• Oversee and implement multiple studies according to timelines, ensuring compliance with GCP, study protocols, SOPs and sponsor requirements.
• Standardise processes for planning, activation, recruitment, enrolment, data cleaning and study close-out.
• Monitor study progress and ensure all performance targets are met.
• Prepare progress reports for funders and stakeholders.
• Collaborate with Principal Investigators to resolve internal and external monitoring findings.
• Ensure accurate maintenance of essential documents and Investigator Site Files.
• Attend community and stakeholder meetings to present study updates.
• Contribute to the development and review of SOPs.

1. Site Management

• Ensure daily operational readiness of the site and clinic facility.
• Allocate staff effectively across multiple studies.
• Conduct regular performance and capacity evaluations.
• Initiate recruitment processes when additional staffing resources are required.
• Act as the primary contact for sponsors and stakeholders.
• Support feasibility assessments by providing accurate site data and capabilities.

1. Staff Training & Mentorship

• Supervise and mentor research staff.
• Conduct training and retraining based on quality assessments and audit feedback.
• Guide staff in development of publications, abstracts, and presentations.
• Promote ongoing professional development.

1. Research Outputs

• Lead or contribute to scientific publications and dissemination activities.
• Lead or support the writing of grant proposals.

Qualifications & Registrations:

• Master’s Degree in Biomedical/Health or related field (Essential)
• Management Qualification (Essential)
• HPCSA Registration, if applicable
• PhD in a Biomedical/Health related field (advantageous).
• Project Management Certificate
• GCP Certification (Advantageous)

Experience:

• Minimum 5 years’ clinical trial management (Essential)
• Minimum 3 years’ clinical research site leadership (Essential)
• Strong understanding of South African regulatory requirements (SAHPRA, Ethics submissions, etc.)
• Experience with study documentation (protocols, CRFs, SOPs)
• Proven track record in publications and grant writing

Additional Requirements:

• Proficiency in English (Essential); Xhosa (Advantageous)
• Proficiency in Microsoft Office
• Ability to utilise Artificial Intelligence (AI) to improve operations
• Willingness to work flexible hours, including weekends as required
• Valid Driver’s License (Essential)

Application Process: