81 Cancer Research jobs in South Africa

Our clinical activities are growing rapidly, and we are currently seeking full-time, home-based Clinical Research Associates to join our Clinical Monitoring team in South Africa. This position will work with a team to accomplish tasks and projects that are instrumental to the company’s success. The Clinical Research Associate at Medpace is offered the unique opportunity to be involved at every stage of the drug development process by providing unrivalled support to our customers. If you want an exciting career where you use your medical or health background and education, travel extensively and are instrumental in the clinical trials process, this could be the opportunity for you.

We kindly ask to submit applications in English.

Entry level associates with research associate or trial assistant-type backgrounds may also be considered.

• Conduct pre-study, initiation, monitoring, and closeout visits for research sites;
• Perform source document verification and case report form review;
• Perform regulatory document review;
• Conduct study drug inventory;
• Perform adverse event and serious adverse event reporting and follow-up;
• Assess patient recruitment and retention.

• Minimum a Bachelor of science in health-related field or equivalent
• Minimum of 1-year independent clinical monitoring; Entry level associates may be considered with relevant trial assistant or research associate-type backgrounds
• Broad knowledge of medical terminology and clinical patient management
• Basic knowledge of drug therapy techniques and clinical research methodologies
• Comprehensive knowledge of Local Regulations and ICH GCP
• Excellent oral and written communication skills
• Fluency in English
• Great attention to detail
• Must hold a valid driver’s license

Medpace is a full-service clinical contract research organization (CRO). We provide Phase I-IV clinical development services to the biotechnology, pharmaceutical and medical device industries. Our mission is to accelerate the global development of safe and effective medical therapeutics through its scientific and disciplined approach. We leverage local regulatory and therapeutic expertise across all major areas including oncology, cardiology, metabolic disease, endocrinology, central nervous system, anti-viral and anti-infective. Headquartered in Cincinnati, Ohio, employing more than 5,000 people across 40+ countries.

People. Purpose. Passion. Make a Difference Tomorrow. Join Us Today.

The work we’ve done over the past 30+ years has positively impacted the lives of countless patients and families who face hundreds of diseases across all key therapeutic areas. The work we do today will improve the lives of people living with illness and disease in the future.

Medpace Perks

• Flexible work environment
• Competitive compensation and benefits package
• Competitive PTO packages
• Structured career paths with opportunities for professional growth
• Company-sponsored employee appreciation events
• Employee health and wellness initiatives

Awards

• Recognized by Forbes as one of America's Most Successful Midsize Companies in 2021, 2022, 2023 and 2024
• Continually recognized with CRO Leadership Awards from Life Science Leader magazine based on expertise, quality, capabilities, reliability, and compatibility

What to Expect Next

A Medpace team member will review your qualifications and, if interested, you will be contacted with details for next steps.

EO/AA Employer M/F/Disability/Vets

CAPRISA is an award-winning global research organisation located on the campus of the Nelson R Mandela School of Medicine in Durban, South Africa and undertakes research in HIV, TB and Covid at four clinical research sites in KwaZulu-Natal. CAPRISA's goal is to undertake globally relevant and locally responsive research that contributes to understanding HIV Vaccines and Pathogenesis, Prevention and Epidemiology, the links between Tuberculosis and AIDS treatment and Covid-19. CAPRISA is a UNAIDS Collaborating Centre for HIV Research and Policy and is recognised as a DSI-NRF Centre of Excellence in HIV Prevention and hosts the SAMRC HIV-TB Pathogenesis and Treatment Research Unit.

The successful incumbent will join the CAPRISA Gates Foundation Vaginal Microbiome Clinical Trials Unit (VM-CTU) and will be based at the CAPRISA Headquarters in Durban.

• A bachelor's degree in a health-related or life sciences discipline (e.g., Pharmacy, Nursing, Medical Sciences, Clinical Research, or equivalent).
• At least 2–3 years of experience monitoring clinical trials with knowledge of clinical trials operations, preferably early-phase (Phase I/II) studies.
• Solid knowledge of SA GCP guidelines, ICH-GCP guidelines, South African Ethics in Health Research Guidelines, SAHPRA and international regulatory requirements.
• Prior experience in monitoring and/or trial coordination, within an academic or as a CRA in industry-sponsored trial setting.
• Strong understanding of investigational product accountability, safety reporting, and protocol compliance.
• Proficiency in MS Office (Word, Excel, PowerPoint, Outlook) and familiarity with electronic data capture (EDC) systems.
• Experience working within a multidisciplinary research environment is an advantage.

• Assume the role of regional monitor for all trials conducted in the VM-CTU for an estimated 5 trials per annum.
• Develop and maintain Standard Operating Procedures relevant to the portfolio.
• Create trial monitoring plans in conjunction with the trial sponsor representatives.
• Conduct study initiation visits for each new trial protocol to assess site readiness for study activation.
• Conduct trial monitoring (clinic, laboratory and pharmacy) to ensure compliance with study protocols, SOPs, ICH-GCP, and local regulatory requirements.
• Review case report forms (CRFs), source documents, and data entry to verify accuracy, completeness, and timeliness.
• Monitor and track protocol deviations, adverse events (AEs/SAEs), and data queries.
• Review essential study documentation, including trial master file (eTMF) and investigator site file (eISF).
• Prepare monitoring reports, progress updates, and assist with audits and inspection preparation.
• Contribute to quality assurance initiatives and continuous improvement of trial conduct at the unit.
• Support close-out activities, ensuring data integrity and regulatory compliance are maintained throughout the trial lifecycle.

Role Description

This is a full-time, on-site role for a Clinical Research Associate based in Durban. The Clinical Research Associate will oversee the daily operations of clinical trials, ensure compliance with protocols, and manage research activities. Responsibilities include coordinating with clinical trial sites, monitoring the progress of studies, and maintaining accurate documentation. The role involves close collaboration with other clinical research professionals to ensure the integrity and quality of the research data.

Responsibilities:

• Assume the role of regional monitor for all trials conducted in the VM-CTU for an estimated 5 trials per annum.
• Develop and maintain Standard Operating Procedures relevant to the portfolio.
• Create trial monitoring plans in conjunction with the trial sponsor representatives.
• Conduct study initiation visits for each new trial protocol to assess site readiness for study activation.
• Conduct trial monitoring (clinic, laboratory and pharmacy) to ensure compliance with study protocols, SOPs, ICH-GCP, and local regulatory requirements.
• Review case report forms (CRFs), source documents, and data entry to verify accuracy, completeness, and timeliness.

Qualifications

• A bachelor's degree in a health-related or life sciences discipline (e.g., Pharmacy, Nursing, Medical Sciences, Clinical Research, or equivalent).
• At least 2–3 years of experience monitoring clinical trials with knowledge of clinical trials operations, preferably early-phase (Phase I/II) studies.
• Solid knowledge of SA GCP guidelines, ICH-GCP guidelines, South African Ethics in Health Research Guidelines, SAHPRA and international regulatory requirements.
• Prior experience in monitoring and/or trial coordination, within an academic or as a CRA in industry-sponsored trial setting.
• Strong understanding of investigational product accountability, safety reporting, and protocol compliance.
• Proficiency in MS Office (Word, Excel, PowerPoint, Outlook) and familiarity with electronic data capture (EDC) systems.
• Experience working within a multidisciplinary research environment is an advantage.

Position
: Clinical Research Nurse

Location:
Bloemfontein – Office based

Job Type:
Full-time

Division:
Clinic

Closing date:
19 September 2025

About Us:

Are you ready to be part of a pioneering force in clinical research? With a rich history dating back to 1974, FARMOVS has been at the forefront of accelerating product development through innovative ICH GCP compliant phase 1-2a clinical trials. Having conducted over 3000 trials at our esteemed facility, we offer unmatched expertise and experience in the field.

At FARMOVS, we pride ourselves on our extensive capabilities, including a GLP certified bioanalytical laboratory, registered pharmacy, and a cutting-edge 98-bed clinic equipped with an ISO 15189 accredited clinical laboratory.

Together, we are pushing the boundaries of medical science and improving lives through groundbreaking clinical research. We collaborate with top-tier institutions and sponsors to conduct clinical trials that pave the way for new treatments and therapies.

Located on the vibrant campus of the University of the Free State in Bloemfontein, central South Africa, FARMOVS offers a dynamic and stimulating work environment.

Position overview:

Are you a compassionate, detail-oriented nursing professional with a passion for advancing healthcare? Then this is the job for you We are seeking a skilled Clinical Research Nurse to join our dynamic team at FARMOVS. A Clinical Research Nurse plays a pivotal role in the healthcare and research sector by coordinating and managing clinical trials according to clinical study protocols, South African and ICH GCP Guidelines and SOPs and ensuring the integrity of the research process while prioritizing patient care.

What we are looking for:

Key Accountabilities:

• Review protocol, Clinical Report Form (CRF) and other related functions (e.g. data transcribing).
• Assist in the recruitment of Trial participants,
• Preparation for execution of studies (e.g. prepare source data), screening and execution of studies.
• Ensure accurate collection, recording, and reporting of trial data in compliance with ethical and regulatory standards.
• Support and educate participants about clinical trials while safeguarding their rights and wellbeing.
• Perform verification and operational QC procedures.
• Working on nominated projects / ad hoc project work and any other protocol specific procedures applicable for which training is given.
• Willing to work flexible hours in terms of day shift and possible night shift hours.

Skills:

• Thorough knowledge of applicable international and local guidelines and regulations (e.g. South African & ICH GCP), SOP's and Basic Life Support;
• Excellent interpersonal, verbal and written communication skills;
• Ability to manage multiple and varied tasks with enthusiasm and prioritize workload with attention to detail;
• Ability to motivate volunteers to be reliable and responsible whilst participating in trials;
• Self-motivated with a willingness to accept responsibility and challenges;
• Ability to work in a team and have a flexible attitude;
• Computer skills; ability to use MS Word, Excel, Outlook;
• Accurate execution of protocol related procedures;
• Able to work independently and with initiative.

Education and Experience:

• B Degree/Diploma in nursing
• Registration with SANC
• Current BLS or ACLS certification
• 2 years' experience as a registered nurse

Why Join Us?

At FARMOVS, you will be part of a collaborative team working on innovative projects that make a real difference. We value teamwork, quality, and a commitment to excellence. If you are ready to take on new challenges and grow your career in Information Technology in the Clinical research environment, we would love to hear from you

How to Apply:

If you are eager to contribute to groundbreaking clinical research and interested in joining our dynamic team, please send your CV to and we will contact you. Should you not receive a personal response from us within two to three weeks after the closing date of the vacancy, you can consider your application to have been unsuccessful.

FARMOVS is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

Are you an experienced professional in the field of Clinical Research who is deeply passionate about contributing to the South African community and committed to making a meaningful impact and taking on a leadership role?

Become part of an organisation dedicated to driving social change and take responsibility for a research site in East London, conducting clinical trials and various projects focused on community engagement, skill development, and alignment with health priorities.

(For the sake of brevity and easy reading, only a key summary of the full job specification / job advert as provided by the client is provided below. Additional information and full details regarding the position and potential employer will be provided following our initial contact and the CV review)

• Lead and oversee multiple clinical studies, ensuring adherence to GCP, protocols, SOPs, and sponsor/internal standards; standardize study processes across planning, activation, recruitment, data management, and closeout phases.
• Monitor study performance, address findings from monitoring reports with PIs, maintain essential documents, provide stakeholder updates, engage with communities, and contribute to SOP development.

• Oversee daily clinic operations, including staff allocation across studies, performance evaluation, and prompt recruitment to ensure optimal site performance and resource availability.
• Act as the main point of contact for sponsors and stakeholders, and support study feasibility assessments by providing insights on site capabilities, patient demographics, and logistics.

• Supervise, mentor, and support site staff to uphold high research standards, including training based on quality and monitoring feedback.
• Promote professional development by guiding staff in scientific writing, presentations, and ongoing skill enhancement.

• Lead and contribute to scientific publications and research dissemination.
• Lead or significantly contribute to writing of grant proposals

• Master’s Degree in a Biomedical/Health related field (essential).
• Current registration with the Health Professions Council of South Africa, if applicable.
• Management qualification (essential).
• PhD in a Biomedical/Health related field (advantageous).
• Project Management qualification (advantageous).
• Valid GCP certification (advantageous).

• Minimum of 5 years’ experience managing clinical trials (essential).
• Minimum of 3 years demonstrated experience in clinical research site management and leading site research teams (essential).
• Comprehensive understanding of the current regulatory requirements pertaining to clinical trials (essential).
• Experience with regulatory submissions to SAHPRA, Ethics Committees, and other regulatory authorities (essential).
• Study trial document development including protocols, case report forms, and SOPS.
• Contribution to scientific publications and grant proposals.

• Proficiency in reading, speaking, and writing English.
• Proficiency in reading, speaking, and writing Xhosa (advantageous).
• Proficiency in Microsoft Office.
• Embracing and leveraging Artificial Intelligence (AI), to enhance operational efficiency.
• Willingness to work reasonable flexible hours, including weekends, if required, in accordance with the BCEA.
• Valid driver’s license (essential).

This role is open to candidates at varying levels, and the final remuneration package will be tailored to reflect your individual qualifications, skills, and experience.

Overview

Are you an experienced professional in the field of Clinical Research who is deeply passionate about contributing to the South African community and committed to making a meaningful impact and taking on a leadership role? Become part of an organisation dedicated to driving social change and take responsibility for a research site in East London, conducting clinical trials and various projects focused on community engagement, skill development, and alignment with health priorities. The clinical research site leader is responsible for providing administrative and operational oversight for the implementation of multiple clinical trials at the site. Key responsibilities include site management, stakeholder collaboration, staff supervision, meeting study deliverables, reporting, maintaining standard operating procedures (SOPs), and supporting team development.

Overview

Together with our client, we are recruiting for a Clinical Research Site Leader based in Zintenteni, Ndevana in the Eastern Cape. The Site Leader will provide administrative and operational leadership in the implementation of multiple clinical trials at the site. This role is accountable for site management, stakeholder coordination, staff supervision, reporting, SOP compliance, and team development, ensuring the successful delivery of all study outcomes.

• Oversee and implement multiple studies according to timelines, ensuring compliance with GCP, study protocols, SOPs and sponsor requirements.
• Standardise processes for planning, activation, recruitment, enrolment, data cleaning and study close-out.
• Monitor study progress and ensure all performance targets are met.
• Prepare progress reports for funders and stakeholders.
• Collaborate with Principal Investigators to resolve internal and external monitoring findings.
• Ensure accurate maintenance of essential documents and Investigator Site Files.
• Attend community and stakeholder meetings to present study updates.
• Contribute to the development and review of SOPs.

• Ensure daily operational readiness of the site and clinic facility.
• Allocate staff effectively across multiple studies.
• Conduct regular performance and capacity evaluations.
• Initiate recruitment processes when additional staffing resources are required.
• Act as the primary contact for sponsors and stakeholders.
• Support feasibility assessments by providing accurate site data and capabilities.

• Supervise and mentor research staff.
• Conduct training and retraining based on quality assessments and audit feedback.
• Guide staff in development of publications, abstracts, and presentations.
• Promote ongoing professional development.

• Lead or contribute to scientific publications and dissemination activities.
• Lead or support the writing of grant proposals.

• Master’s Degree in Biomedical/Health or related field (Essential)
• Management Qualification (Essential)
• HPCSA Registration, if applicable
• PhD in a Biomedical/Health related field (advantageous)
• Project Management Certificate
• GCP Certification (Advantageous)

• Minimum 5 years’ clinical trial management (Essential)
• Minimum 3 years’ clinical research site leadership (Essential)
• Strong understanding of South African regulatory requirements (SAHPRA, Ethics submissions, etc.)
• Experience with study documentation (protocols, CRFs, SOPs)
• Proven track record in publications and grant writing

• Proficiency in English (Essential); Xhosa (Advantageous)
• Proficiency in Microsoft Office
• Ability to utilise Artificial Intelligence (AI) to improve operations
• Willingness to work flexible hours, including weekends as required
• Valid Driver’s License (Essential)

How to Apply: To apply, please send your CV and any supporting documents to with the subject line "Clinical”

Closing Date: 12 October 2025 at 16h00

Overview

Job Title: Clinical Research Site Leader

Department: Research Department

Reports to: Head of Research

Location: Ndevana, Buffalo City Metropolitan Municipality in the Eastern Cape

Annual Salary Range: R737 796 – R1 009 077 (Depending on experience)

Purpose of the Role

Together with our client, we are recruiting for a Clinical Research Site Leader based in Zintenteni, Ndevana in the Eastern Cape. The Site Leader will provide administrative and operational leadership in the implementation of multiple clinical trials at the site. This role is accountable for site management, stakeholder coordination, staff supervision, reporting, SOP compliance, and team development, ensuring the successful delivery of all study outcomes.

• Project Management
  • Oversee and implement multiple studies according to timelines, ensuring compliance with GCP, study protocols, SOPs and sponsor requirements.
  • Standardise processes for planning, activation, recruitment, enrolment, data cleaning and study close-out.
  • Monitor study progress and ensure all performance targets are met.
  • Prepare progress reports for funders and stakeholders.
  • Collaborate with Principal Investigators to resolve internal and external monitoring findings.
  • Ensure accurate maintenance of essential documents and Investigator Site Files.
  • Attend community and stakeholder meetings to present study updates.
  • Contribute to the development and review of SOPs.
• Site Management
  • Ensure daily operational readiness of the site and clinic facility.
  • Allocate staff effectively across multiple studies.
  • Conduct regular performance and capacity evaluations.
  • Initiate recruitment processes when additional staffing resources are required.
  • Act as the primary contact for sponsors and stakeholders.
  • Support feasibility assessments by providing accurate site data and capabilities.
• Staff Training & Mentorship
  • Supervise and mentor research staff.
  • Conduct training and retraining based on quality assessments and audit feedback.
  • Guide staff in development of publications, abstracts, and presentations.
  • Promote ongoing professional development.
• Research Outputs
  • Lead or contribute to scientific publications and dissemination activities.
  • Lead or support the writing of grant proposals.

• Master’s Degree in Biomedical/Health or related field (Essential)
• Management Qualification (Essential)
• HPCSA Registration, if applicable
• PhD in a Biomedical/Health related field (advantageous)
• Project Management Certificate
• GCP Certification (Advantageous)

• Minimum 5 years’ clinical trial management (Essential)
• Minimum 3 years’ clinical research site leadership (Essential)
• Strong understanding of South African regulatory requirements (SAHPRA, Ethics submissions, etc.)
• Experience with study documentation (protocols, CRFs, SOPs)
• Proven track record in publications and grant writing

• Proficiency in English (Essential); Xhosa (Advantageous)
• Proficiency in Microsoft Office
• Ability to utilise Artificial Intelligence (AI) to improve operations
• Willingness to work flexible hours, including weekends as required
• Valid Driver’s License (Essential)

How to Apply: To apply, please send your CV and any supporting documents to with the subject line "Clinical”

12 October 2025 at 16h00